Low-dose Nalmefene
Low-dose nalmefene significantly shortened the time to PACU recovery readiness compared with saline. The trial frames the approximately 9-10 minute reduction in PACU recovery endpoint time as clinically meaningful. A single intravenous nal…
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Low-dose nalmefene significantly shortened the time to PACU recovery readiness compared with saline. The trial frames the approximately 9-10 minute reduction in PACU recovery endpoint time as clinically meaningful. A single intravenous nalmefene dose of 0.25 micrograms/kg was administered at completion of skin suturing in the intervention group. Nalmefene is described as a long-acting antagonist of mu, kappa, and delta opioid receptors. The precise mechanisms by which low-dose nalmefene preserved or improved analgesia remain unresolved.