Low-Grade Albuminuria
The Framingham Heart Study found that low UACR predicted cardiovascular events and all-cause mortality over 6 years in non-diabetic, non-hypertensive participants, independent of traditional risk factors. Each 1 mg/g increase in UACR withi…
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The Framingham Heart Study found that low UACR predicted cardiovascular events and all-cause mortality over 6 years in non-diabetic, non-hypertensive participants, independent of traditional risk factors. Each 1 mg/g increase in UACR within the normal range corresponded to a 2% increase in MACE risk. The 2% relative MACE increase per 1 mg/g UACR within the normal range is modest at the individual level but meaningful as a population-level risk gradient. Even within the normal UACR range below 30 mg/g, increasing UACR was significantly associated with higher MACE risk. After full multivariable adjustment, the highest tertile of low-grade albuminuria remained significantly associated with acute myocardial infarction but the finding is considered preliminary pending further validation.