Luria-Delbruck Model
Replication limits reduce the expected number of mutants in the Luria-Delbruck formulation at all nonnegative times. The Luria-Delbruck framework was developed to distinguish spontaneous mutation from adaptive mutation in bacteria. Classic…
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Replication limits reduce the expected number of mutants in the Luria-Delbruck formulation at all nonnegative times. The Luria-Delbruck framework was developed to distinguish spontaneous mutation from adaptive mutation in bacteria. Classical Luria-Delbruck models assume wild-type cells can divide indefinitely. In the deterministic Luria-Delbruck formulation, the probability of no mutants equals the probability that no mutations have occurred. In the Luria-Delbruck formulation, mutations occur as a Poisson process with rate proportional to the dividing wild-type population.