MDS-UPDRS
The practically defined OFF-medication state is defined as no anti-PD medication taken for more than 12 hours. MDS-UPDRS Part 3 assesses motor function on a total score range of 0–132, with higher scores indicating greater severity. Measur…
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The practically defined OFF-medication state is defined as no anti-PD medication taken for more than 12 hours. MDS-UPDRS Part 3 assesses motor function on a total score range of 0–132, with higher scores indicating greater severity. Measuring the primary outcome after the 12-week washout is intended to detect a residual change in disease trajectory rather than a symptomatic drug effect. The primary endpoint is the change in MDS-UPDRS Part 3 score from baseline to week 48, measured in the practically defined OFF-medication state.