Medication Research in Pregnancy
One MR study of 1,139 maternal and fetal circulating proteins implicated glucose metabolism, energy balance, and vascular function in offspring birth weight. MR-PREG found signals that PCSK1 and LGALS4 may influence birth weight differentl…
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One MR study of 1,139 maternal and fetal circulating proteins implicated glucose metabolism, energy balance, and vascular function in offspring birth weight. MR-PREG found signals that PCSK1 and LGALS4 may influence birth weight differently depending on whether maternal or fetal genetically predicted protein levels are considered. MR-PREG aims to use genomics to evaluate medication safety and efficacy during pregnancy. MR-PREG uses drug target MR to investigate drugs for pre-existing conditions, identify new candidate drug targets, and find repurposing opportunities. Future work includes discovering candidate drug targets and assessing safety, efficacy, and repurposing potential of existing drugs during pregnancy.