Melanocyte-Stimulating Hormone
Improving insulin resistance reduces MSH stimulation via the insulin pathway, causing dark circles to lighten. Elevated MSH stimulates melanocytes in the skin to overproduce melanin. ACTH and MSH share the same precursor molecule (POMC), s…
1 sources - 4 claims
Improving insulin resistance reduces MSH stimulation via the insulin pathway, causing dark circles to lighten. Elevated MSH stimulates melanocytes in the skin to overproduce melanin. ACTH and MSH share the same precursor molecule (POMC), so chronically elevated ACTH drives a parallel rise in MSH. Chronically elevated insulin stimulates MSH through melanocyte insulin receptors and IGF-1 receptor cross-reactivity.