Mendelian Randomisation
MR can reduce confounding from socioeconomic, behavioural, and health-related factors that affect conventional observational analyses. MR depends on instruments being associated with the exposure, independent of confounders, and affecting…
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MR can reduce confounding from socioeconomic, behavioural, and health-related factors that affect conventional observational analyses. MR depends on instruments being associated with the exposure, independent of confounders, and affecting outcomes only through the exposure. Mendelian randomisation uses randomly allocated genetic variants at conception to infer causal effects of modifiable exposures on outcomes. Drug target MR uses genetic proxies for drug targets to evaluate likely medication effects.