Methylation Pathway
The methylation pathway converts homocysteine back into methionine. Homocysteine methylation requires B6, B2, folate, and B12 as cofactors or methyl-transfer support. Inadequate B vitamins can stall methylation and lead to homocysteine bui…
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The methylation pathway converts homocysteine back into methionine. Homocysteine methylation requires B6, B2, folate, and B12 as cofactors or methyl-transfer support. Inadequate B vitamins can stall methylation and lead to homocysteine buildup. TMG is presented as an additional methyl donor when B-vitamin therapy does not normalize homocysteine.