MEX-CD1
Preclinical studies found improved iron removal with MEX-CD1 at dialysate concentrations about twice those planned for the trial. MEX-CD1 has an approximately 300 kDa molecular weight that prevents crossing of the dialysis membrane. MEX-CD…
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Preclinical studies found improved iron removal with MEX-CD1 at dialysate concentrations about twice those planned for the trial. MEX-CD1 has an approximately 300 kDa molecular weight that prevents crossing of the dialysis membrane. MEX-CD1 is described as continuously enhancing the iron extraction gradient without saturation. MEX-CD1 is added to dialysate so that it remains confined to the dialysis circuit and avoids systemic exposure. MEX-CD1 is a chelating polymer made from reacetylated chitosan functionalised by DOTAGA ligands.