MGMT Promoter Methylation
MGMT promoter methylation is associated with reduced repair capacity and better temozolomide response and prognosis. MGMT promoter methylation is clinically important because MGMT repairs alkylation damage at the O6 position of guanine. Un…
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MGMT promoter methylation is associated with reduced repair capacity and better temozolomide response and prognosis. MGMT promoter methylation is clinically important because MGMT repairs alkylation damage at the O6 position of guanine. Unmethylated MGMT contributes to temozolomide resistance by maintaining DNA repair activity. MGMT status is especially relevant for treatment selection in elderly patients.