Microcirculation
Semi-automated analysis is preferred over fully automated software because numeric results can differ substantially and affect agreement. Circulating tissue-integrity markers including thrombomodulin, syndecan-1, asymmetric dimethylarginin…
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Semi-automated analysis is preferred over fully automated software because numeric results can differ substantially and affect agreement. Circulating tissue-integrity markers including thrombomodulin, syndecan-1, asymmetric dimethylarginine, actin, gelsolin, gc-globulin, and DNase-1 are measured by ELISA and/or LC-MS. Oral microcirculation is assessed through sublingual sidestream dark field videomicroscopy using AVA V.4.3 software. The non-acute study setting allows multiple measures, and the protocol estimates approximately 15 minutes per microcirculation assessment.