Midodrine Safety

Patients are monitored daily for adverse events attributable to midodrine. Safety monitoring includes bradycardia, ischemic events, hypertension, allergic reactions, acute kidney injury, atrial fibrillation, urinary retention, severe myoclonus, dermatologic effects, and sensory disturbances. In the prior observational cohort, mild asymptomatic bradycardia was the most common adverse effect. Bowel ischemia occurred in 0.2% of patients in the prior observational cohort, but causality was inconclusive.