Moderators

Subgroup analyses examine MBCT efficacy and moderators separately across non-responders, treatment-resistant patients, and chronic depression patients. Gender, age, and prior digital health experience moderated the transition from behavioural intention to actual use, while education did not. Prior digital health experience strengthened conversion of behavioural intention into actual use. Relatively younger older adults were more likely to convert intention into use. Men were more likely than women to translate intention into actual use. Education did not significantly moderate the intention-to-use relationship. Moderator analyses test treatment-covariate interactions in the main IPD-MA model. Age under 1 year was the strongest independent predictor of hypoxaemia. Comorbidities and prolonged surgery duration had the highest adjusted odds for bradycardia. Surgery type was not independently associated with hypoxaemia or bradycardia after adjustment. Respiratory disease comorbidity was the strongest categorical predictor of bradycardia. The review aims to identify patient-level and study-level characteristics that predict differential response to MBCT versus control.