MolClock

Using skin-specific methylation data made the model more accurate at predicting skin biological age. The Mo clock was reported to predict skin age better than other available clocks for this use case. MolClock was developed because general clocks such as the Horvath clock were not sufficiently accurate for skin in OneSkin's work. Training on skin samples helps the clock capture methylation patterns most relevant to skin aging. MolClock uses skin-only samples to predict skin biological age more accurately than broader clocks. MolClock is biopsy-based, making studies invasive and expensive. A methylation clock trained only on skin samples was developed because the Horvath clock had limited skin-age accuracy. MolClock enabled testing of peptides and products using methylation profiles before and after treatment. A non-invasive method for collecting enough biological material to measure skin age is described as a future goal.