MRI Radiogenomics

The article interprets contrast-enhanced MRI as potentially more directly informative for MGMT status than pixel-wise averaged multi-sequence fusion. The article identifies spatial heterogeneity and high-dimensional correlated MRI data as central barriers for MGMT prediction. T1Gd is used as the reference modality because gadolinium enhancement highlights active tumor-related regions. Prior MRI-based CNN and radiomics approaches used modalities including FLAIR, T1w, T1Gd, T2, DWI, ADC, ASL, and mpMRI. The study addresses non-invasive prediction of MGMT promoter methylation from MRI.