MTHFR Gene Mutation

Those with an MTHFR mutation should supplement with methyl B12 and folinic acid instead of standard B vitamins. Standard cyanocobalamin B12 supplements are largely ineffective for people with MTHFR mutations. The MTHFR mutation is not rare, affecting approximately 20% of the population. Mutations in the MTHFR gene affect 30 to 50 percent of the population. MTHFR mutations are extremely common in the general population. Between 40% and 50% of the population carries a variant in the MTHFR gene. Approximately 30% of the population carries a variant in the MTHFR gene. Choline absorption can be genetically impaired, requiring higher dietary intake from liver and egg yolks. The MTHFR mutation impairs the body's ability to convert synthetic B12 and folic acid into their active, usable forms. The MTHFR enzyme is responsible for converting folate or folic acid into methylfolate, the active form the body can use. The MTHFR gene is responsible for activating folate and is functionally coupled to B12 metabolism. The MTHFR gene governs methylation, the biochemical process enabling detoxification, gene expression, and many metabolic functions. The MTHFR gene mutation prevents the conversion of…