Multimodal Analgesia

Opioids in postoperative pain regimens can cause nausea, respiratory depression, and addiction risk. Single analgesic agents may be insufficient for high-intensity postoperative pain. Opioid-sparing multimodal analgesia aims to reduce pain…

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Opioids in postoperative pain regimens can cause nausea, respiratory depression, and addiction risk. Single analgesic agents may be insufficient for high-intensity postoperative pain. Opioid-sparing multimodal analgesia aims to reduce pain while lowering opioid exposure and opioid-related adverse effects. Current postoperative pain management commonly combines medications with different mechanisms to block pain transmission at multiple targets.