Network pharmacology
The compound-target and HeLa-target intersection produced 62 common targets. STRING protein-protein interaction analysis prioritized TNF, CTNNB1, SRC, NFKB1, and MTOR as central targets. Network analysis connected prioritized xanthones to…
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The compound-target and HeLa-target intersection produced 62 common targets. STRING protein-protein interaction analysis prioritized TNF, CTNNB1, SRC, NFKB1, and MTOR as central targets. Network analysis connected prioritized xanthones to pathways involving apoptosis regulation, inflammatory signaling, Wnt/beta-catenin signaling, NF-kappaB signaling, mTOR complexes, and cancer-related enrichment. Network pharmacology was used to identify likely active compounds and target proteins.