Neuroinflammation Treatment

IVIG restores IgG subclass content in patients with documented deficiency, reducing susceptibility to recurrent infections and the downstream neuroinflammatory cascade. Taking both H1 and H2 antihistamines during and for approximately six weeks after acute infection reduces mast cell activation and lowers the risk of long-term neuroinflammatory sequelae including long-COVID. Low-dose naltrexone is effective for treating hyperreactive microglia, the brain's resident immune cells and a primary driver of neuroinflammation. Andrographis has been shown in studies to reduce the incidence of all lung infections by approximately 20% and to reduce both duration and severity of symptoms. CBD can quiet microglial activation and reduce brain inflammation, but efficacy varies significantly by strain and product with insufficient standardization for universal recommendations. Many patients with recurrent infections have a dropout of one of the four IgG subclasses, preventing a proper immune response to certain pathogens and explaining repeated susceptibility. Chronic NSAID use causes ulceration in approximately 75% of users throughout the entire gastrointestinal tract, not only the stomach, sil…