Nitric Oxide Synthase
NOS uncoupling is described as a state where NOS produces superoxide instead of nitric oxide. Nitric oxide synthase is the enzyme family that produces nitric oxide. NOS2 is induced during inflammation, injury, or infection and can produce…
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NOS uncoupling is described as a state where NOS produces superoxide instead of nitric oxide. Nitric oxide synthase is the enzyme family that produces nitric oxide. NOS2 is induced during inflammation, injury, or infection and can produce much larger nitric oxide outputs. NOS1 and NOS3 are described as constitutively expressed, calcium-regulated isoforms that generate nitric oxide on demand. Acute NOS2 activation can support antimicrobial defense, while chronic activation can produce oxidative and nitrosative stress.