NRF2

Nrf2 activation decreases cellular stress by reducing oxidative damage at the cellular level. Nrf2-activating herbs function as long-term system enhancers that raise the baseline capacity of the body's detox machinery. High NRF2 expression is associated with the naked mole rat's approximately 30-year lifespan, which is extraordinarily long for a rodent of its size. NRF2 is present in humans, but naked mole rats express it at a far higher level. Nrf2 activation triggers expression of over 200 different genes involved in protective functions. NRF2 is described as the master regulator of oxidative stress protection. The Nrf2 pathway is the gene-level switch that governs how much glutathione and SOD the body produces. NRF2 upregulates the body's endogenous antioxidant systems, providing protection against reactive oxygen species. NRF2 stimulates autophagy, the cellular process of identifying and degrading damaged or misfolded proteins, reducing stress-related cellular debris. One function of Nrf2 activation is upregulating the body's internal antioxidant defenses. Nrf2 activation supports detoxification by converting poisons and harmful substances into harmless particles via liver det…