Nuchido Time+

The formula without any NAD precursor still produced approximately a 90% increase in cellular NAD, demonstrating that restoring recycling capacity is itself a meaningful intervention. The full formula with a NAD precursor produced an average 242% increase in NAD over two weeks in a small human pilot study. A larger randomized, double-blinded, placebo-controlled crossover trial enrolling participants aged 20–80 of both sexes is ongoing. Piperine in the formula non-selectively increases gut absorption and will raise the bioavailability of prescription medications taken simultaneously. Other vitamin B3 derivatives should not be taken concurrently with Time+ to avoid exceeding the daily safe upper limit for vitamin B3. Nuchido Time+ was designed to repair the root causes of NAD decline rather than simply supply more NAD precursors.