Obesity

A 5–10% body-weight reduction over 6 months is considered clinically meaningful. The lowest risk of hypertension is generally observed in the normal BMI range of approximately 18.5–24 kg/m². Asian-specific BMI cut-offs used in the study classify obesity at a lower threshold than WHO global cut-offs. The article asserts that humans experience epidemic obesity unlike other animal species. References on GLP-1 receptor agonist discontinuation are part of the clinical context for obesity treatment and weight regain. In South Asia, overweight and obesity prevalence peaks at a younger age than in high-income countries. Obesity is defined as excess body fat that harms health and reduces life expectancy. The article treats obesity as a chronic metabolic disease characterised by excessive adiposity. HARMONY defines overweight as BMI 24–27.9 kg/m² and obesity as BMI at least 28 kg/m². The review uses a BMI threshold of at least 25 kg/m² for overweight or obesity eligibility, with a lower threshold of at least 23 kg/m² for the Asia-Pacific region. The background citations frame obesity and overweight as major global health problems. Cohort studies and a dose-response meta-analysis show graded…