Oncotic Pressure
Albumin, produced by the liver, creates oncotic pressure that holds water inside blood vessels. Kidney disease causes protein to leak into urine (proteinuria), lowering oncotic pressure and causing fluid retention. Liver cirrhosis and seve…
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Albumin, produced by the liver, creates oncotic pressure that holds water inside blood vessels. Kidney disease causes protein to leak into urine (proteinuria), lowering oncotic pressure and causing fluid retention. Liver cirrhosis and severe fatty liver disease impair albumin production, causing fluid to escape into tissues. Advanced liver disease characteristically causes edema on the right ankle and leg before the left.