Opioid Risk Prediction

The adverse opioid outcome was rare and class-imbalanced, with positive cases weighted more heavily during training. Adverse opioid outcomes occurred in only about 2–3% of dispensations, creating overfitting risks. The primary prediction t…

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The adverse opioid outcome was rare and class-imbalanced, with positive cases weighted more heavily during training. Adverse opioid outcomes occurred in only about 2–3% of dispensations, creating overfitting risks. The primary prediction target was a 30-day composite of opioid-related ED visit, hospitalisation, or death after each opioid dispensation. The unit of analysis was each opioid dispensation event rather than each patient.