Organic Acid Testing

The organic acids profile pairs with the GI Map to give a more comprehensive metabolic and microbial picture for complex or multi-system cases. Using a toxicant panel together with the OAT gives a more complete clinical picture than either test alone. Elevated pyruvate on organic acids testing is the earliest detectable warning sign of insulin resistance. Results are reported in quintiles based on a healthy cohort reference population. The OAT complements toxicant testing by showing functional cellular effects rather than only chemical presence. Organic acid testing is superior to direct plasma vitamin measurements because SNPs can alter protein shape and impair enzyme binding even when substrate concentrations appear normal. Urinary neurotransmitter concentrations should not be interpreted as direct correlates of CNS neurotransmitter levels. The lab uses tandem mass spectrometry to provide high specificity and sensitivity. Single organic acid markers should be interpreted within the full panel rather than in isolation. Dietary sources of some organic acids must be considered when interpreting OAT results. Metformin use and recent intense exercise independently elevate lactate and…