Outcomes and Evidence Certainty
Risk of bias will be assessed with the revised Cochrane Risk of Bias tool for randomized trials. Evidence certainty will be evaluated with GRADE across five domains and rated from high to very low. Network meta-analysis evidence will also…
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Risk of bias will be assessed with the revised Cochrane Risk of Bias tool for randomized trials. Evidence certainty will be evaluated with GRADE across five domains and rated from high to very low. Network meta-analysis evidence will also be assessed with CINeMA separately for lifestyle or behavioural and device-based interventions. Secondary outcomes include natriuretic peptide biomarkers and cardiac function measures. The detailed methods define primary outcomes as exercise capacity and health-related quality of life.