OVRV1
OVRV2 was detected only in the L2 larval stage, which is not transmitted to humans, making its relevance to human disease negligible. Viral metagenomics and transcriptome analysis identified two potential pathogenic rhabdoviruses in O. vol…
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OVRV2 was detected only in the L2 larval stage, which is not transmitted to humans, making its relevance to human disease negligible. Viral metagenomics and transcriptome analysis identified two potential pathogenic rhabdoviruses in O. volvulus: OVRV1 and OVRV2. OVRV1 is hypothesised to play a role in OAE pathogenesis. OVRV1 has been detected in most tested adult O. volvulus worms, microfilariae, and larvae. The study will assess whether OVRV1, if detected in CSF, can infect neural cells and exhibit neurotropism or neurotoxicity.