Paediatric Medicines

Children's dosing is often extrapolated from adult studies and adjusted for body weight. Paediatric populations require granular dosing and formulations tailored to developmental and clinical differences. Paediatric formulations can be delayed long after adult medicines are available. Adult-to-child dose extrapolation can be inadequate because children and adults may respond differently even after weight adjustment. Crushing tablets for infants and small children can reduce tolerability and risk subtherapeutic dosing.