Patient-Reported Outcomes

Functional ability measured by the Hannover FFbH improved from 62% at baseline to 73% at month 24, approaching normal functional ability. Arthritis pain on a visual analogue scale decreased from a mean of 55 mm at baseline to 30 mm at month 24. Mean morning stiffness decreased from 60 minutes at baseline to 21 minutes at month 24. Quality of life measured by EuroQoL 5-Dimension 3-Level VAS improved from 47 mm at baseline to 67 mm at month 24. FACIT fatigue scores improved from 30 at baseline to 37 at month 24, indicating decreased fatigue burden. Failure to attain low disease activity remained associated with worse patient-reported outcomes after adjustment. Clinical outcomes improved significantly at 1 year across Oxford Knee Score, KOOS, EQ-5D, and VAS pain measures. Prior PROM studies have reported benefits including earlier symptom recognition and improved shared decision-making. Integrating PROMs into oncology care can improve health-related quality of life and may improve survival. The FDA Clinical Outcome Assessments framework includes clinician-reported, observer-reported, objective performance, and patient-reported outcomes. Patients consistently not at target had the wor…