Persistent Depressive Disorder

Inpatients with persistent depressive disorder have lower response rates and higher relapse risk than inpatients with non-chronic depression. Persistent depressive disorder affects about 20% to 30% of people with depression and has an estimated lifetime prevalence of 3% to 6%. There is a lack of evidence-based inpatient treatments for people with persistent depressive disorder. Persistent depressive disorder is associated with psychosocial impairment, comorbidities, suicidality, and treatment resistance.