Phase Ia Trial Design

The single-centre, single-arm design limits generalisability and introduces potential bias. The trial evaluates intrathecal pemetrexed with or without intrathecal bevacizumab in advanced NSCLC patients with confirmed leptomeningeal metasta…

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The single-centre, single-arm design limits generalisability and introduces potential bias. The trial evaluates intrathecal pemetrexed with or without intrathecal bevacizumab in advanced NSCLC patients with confirmed leptomeningeal metastases.