Phosphatidylserine

Phosphatidylserine changes the entire shape of the stress response by reducing both how high cortisol rises and how long it remains elevated, unlike Vitamin C which only reduces the peak. 800 mg per day of phosphatidylserine reduced cortisol by about 30% when measured as area under the curve across the entire stress response. Some individuals may experience an effect at 300 mg per day rather than the study dose of 800 mg, but this is highly individual. Phosphatidylserine is a phospholipid structural component of cell membranes and is especially important in brain cells. Phosphatidylserine helps the brain shut off the stress response once it is no longer needed, making it useful for people whose stress remains activated too long. Rather than directly reducing cortisol production, phosphatidylserine influences how the brain interprets and responds to stress signals. SunPS, a trademarked version of phosphatidylserine, is recommended because its potency is more consistent than unbranded forms.