Placental Transfer
Rat reproductive toxicology found DM199 in maternal blood but not fetal blood after gestational administration. Macromolecules such as proteins require specific carrier transport proteins to cross the syncytiotrophoblast surface of the pla…
1 sources - 4 claims
Rat reproductive toxicology found DM199 in maternal blood but not fetal blood after gestational administration. Macromolecules such as proteins require specific carrier transport proteins to cross the syncytiotrophoblast surface of the placenta. DM199 is structurally unlikely to cross the placental barrier because it is a large protein molecule.