Plasma Classifier Development
Clinical-only, protein-only, and combined models are compared by ROC/AUC. Internally validated models are tested in an independent validation cohort using targeted mass spectrometry. Elastic net modelling selects a stable, parsimonious pre…
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Clinical-only, protein-only, and combined models are compared by ROC/AUC. Internally validated models are tested in an independent validation cohort using targeted mass spectrometry. Elastic net modelling selects a stable, parsimonious predictor set while controlling for overfitting. Candidate clinical variables, patient-reported outcomes, and protein markers are first screened using univariate logistic regression.