Pre-Diabetes

Lifestyle interventions targeting impaired glucose tolerance can substantially reduce type 2 diabetes incidence. Early detection and lifestyle intervention in pre-diabetic individuals can reduce the risk of progression to type 2 diabetes by up to 49%. Cambodia's HbA1c-based pre-diabetes prevalence is approximately three times the global FBG-based estimate and approximately five times Cambodia's own 2023 STEPS survey figure. HbA1c criteria identify more pre-diabetic individuals than fasting blood glucose criteria alone. This study is the first nationally representative analysis of pre-diabetes in Cambodia to include adults across all age groups from 18 upwards. Insulin resistance is driven by repeated high insulin exposure over time, which causes cells to respond less effectively. Metabolic prevention should target insulin dysfunction rather than only glucose values. The article says near-to-medium-term cardiovascular disease risk in this population appears to be driven more by haemodynamic and lipid axes than by glycaemic factors. Prediabetes and insulin resistance can damage metabolic systems before obvious symptoms appear. Baseline HbA1c was not measured in all participants, so…