Primary Progressive Aphasia
PPA has three recognized clinical variants. Primary progressive aphasia is characterized by progressive language deterioration as the main cause of functional decline. All PPA variants mainly affect the language-dominant hemisphere. The no…
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PPA has three recognized clinical variants. Primary progressive aphasia is characterized by progressive language deterioration as the main cause of functional decline. All PPA variants mainly affect the language-dominant hemisphere. The non-fluent/agrammatic and semantic variants are mainly associated with frontotemporal degeneration, while the logopenic variant is linked more closely to Alzheimer's disease pathology.