Progesterone

Progesterone plays a crucial role in mood regulation and emotional stability. Progesterone is one of the most potent neuroprotective hormones and stimulates autophagy in the spinal column. Patients on bioidentical progesterone frequently report improved sleep onset, reduced nighttime waking, and decreased anxiety. Restoring progesterone levels through supplementation can reverse depression caused by deficiency. Progesterone keeps inflammation in brain cells low, directly countering LH-driven neuroinflammation. Progesterone is a critical component of overall bone strength and calcium metabolism. Women with higher progesterone levels show less severe outcomes after traumatic brain injury than men with the same injury severity. Topical progesterone applied to breast tissue decreased cell proliferation in women awaiting biopsy for benign lesions. Progesterone is referred to as the happy hormone. Micronized progesterone has not been implicated in thrombosis or breast cancer, unlike MPA which increases thrombosis risk. In the Medicare study, progestins used alone increased breast cancer risk by 21%, whereas progesterone alone decreased it by 10%. Synthetic progestins produce metabolites…