Prophylaxis-Associated Harms

High prescribers were less concerned about the risks of administering prophylaxis and less concerned about prophylaxis overuse compared to low prescribers. Low prescribers showed stronger disagreement with the notion that prophylaxis has no downside, reflecting greater awareness that unnecessary prophylaxis carries real harm. Interventions to reduce overtreatment should include educating physicians on actual observed rates of prophylaxis-associated harm such as bleeding and heparin-induced thrombocytopenia.