Protein-Coding Genes
The article says humans and mice share more than 80% of orthologous protein-coding genes despite large lifespan differences. Relative protein-coding length was negatively associated with lifespan. Across the main dataset, absolute protein-…
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The article says humans and mice share more than 80% of orthologous protein-coding genes despite large lifespan differences. Relative protein-coding length was negatively associated with lifespan. Across the main dataset, absolute protein-coding length was not significantly correlated with lifespan. The paper interprets protein-coding content as insufficient to explain lifespan extension. The proposed mechanism argues that protein synthesis and protein function are more energy-consuming than ncRNA-based regulation.