Psoriasis

Modern biologics targeting inflammatory cytokines are highly effective for moderate-to-severe psoriasis but are expensive and can cause side effects that may reduce adherence. Comparisons with psoriasis showed more pronounced and consistent psychiatric comorbidity differences than comparisons with atopic dermatitis. Psoriasis is a systemic inflammatory disease with statistically validated comorbidities spanning virtually every organ system. The skin-brain axis links psychological states bidirectionally with immune and inflammatory skin processes. Psoriasis is lifelong, relapsing and remitting, and associated with physical, emotional, functional, and psychosocial burdens. Itch is common in psoriasis and affects about 85% of patients. Itch in psoriasis contributes to emotional distress, impaired functioning, and reduced quality of life. People with vitiligo had higher risk of obsessive-compulsive personality disorder than people with psoriasis, and the effect persisted across all three case definitions. Hyperkinetic disorders were consistently higher in people with vitiligo than in people with psoriasis across all definitions. Cardiovascular disease risk is significantly elevated in…