Psychological Factors

Psychological well-being may begin worsening before a formal mild cognitive impairment diagnosis. Depression mediated part of the association between cognitive impairment and both cardiovascular death and composite CVD outcomes. Declines i…

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Psychological well-being may begin worsening before a formal mild cognitive impairment diagnosis. Depression mediated part of the association between cognitive impairment and both cardiovascular death and composite CVD outcomes. Declines in cognitive domains may promote social isolation, anxiety, and loneliness that increase cardiovascular risk. The article identifies depression and anxiety management as potential targets for reducing excess cardiovascular risk in cognitively impaired populations.