PTHrP
Hypercalcemia caused by tumor PTHrP secretion is a known clinical marker of cancer. Approximately 80% of tumors produce PTHrP, a protein that mimics parathyroid hormone and extracts calcium from bones as a cancer survival mechanism. Excess…
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Hypercalcemia caused by tumor PTHrP secretion is a known clinical marker of cancer. Approximately 80% of tumors produce PTHrP, a protein that mimics parathyroid hormone and extracts calcium from bones as a cancer survival mechanism. Excess blood calcium from PTHrP-driven hypercalcemia inhibits vitamin D, allowing cancer to suppress immune regulation while simultaneously depleting bone nutrients.