Pulmonary Endothelium
Hantavirus infection makes tight pulmonary endothelial junctions leaky. Endothelial barrier failure makes alveoli wet and vascular circulation depleted, causing respiratory failure and shock together. The pulmonary endothelial barrier must…
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Hantavirus infection makes tight pulmonary endothelial junctions leaky. Endothelial barrier failure makes alveoli wet and vascular circulation depleted, causing respiratory failure and shock together. The pulmonary endothelial barrier must keep plasma inside blood vessels while allowing gas exchange across thin lung structures. Severe endothelial permeability can allow red blood cells to enter the alveoli.