QALY Estimation
Fatigue Severity Scale scores were mapped to SF-6D utilities using a Goodwin et al. regression model. Most studies did not directly report health utility values, so the model used a mapping algorithm. QALYs were estimated using an area-und…
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Fatigue Severity Scale scores were mapped to SF-6D utilities using a Goodwin et al. regression model. Most studies did not directly report health utility values, so the model used a mapping algorithm. QALYs were estimated using an area-under-the-curve approach across end-of-treatment, short-term, and long-term time points. The base-case time horizon was 24 months from baseline. Fatigue outcomes were pooled as standardized mean differences and converted to Fatigue Severity Scale score differences. After the final follow-up, treatment effects were assumed to decline linearly to zero by 24 months.