Random Breakage Model
RBM is modeled as the special case where all potentially breakable sites are fragile and there is no turnover. Pairwise human-mouse breakpoint reuse contradicted RBM. RBM was historically supported by an exponential distribution of human-m…
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RBM is modeled as the special case where all potentially breakable sites are fragile and there is no turnover. Pairwise human-mouse breakpoint reuse contradicted RBM. RBM was historically supported by an exponential distribution of human-mouse synteny block lengths. The Random Breakage Model assumes mammalian chromosomal rearrangements do not occur in hotspots. RBM predicts no systematic decline in multispecies breakpoint reuse by evolutionary distance.