Rebound Acid Hypersecretion
Even asymptomatic volunteers may develop upper gastrointestinal symptoms after stopping PPIs following 4 to 8 weeks of treatment. Rebound acid hypersecretion is described as a central barrier to stopping PPIs. Gastrin levels rise during ac…
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Even asymptomatic volunteers may develop upper gastrointestinal symptoms after stopping PPIs following 4 to 8 weeks of treatment. Rebound acid hypersecretion is described as a central barrier to stopping PPIs. Gastrin levels rise during acid suppression. After PPI interruption, increased acid secretion may occur for up to 2 weeks. Rebound symptoms can lead patients to restart PPIs.