Reduced-Fluence Photodynamic Therapy

Reduced-intensity PDT protocols achieved comparable efficacy with fewer complications than full-fluence PDT. REPLAY was preceded by no large prospective placebo-controlled randomised trial specifically evaluating rf-PDT for chronic CSC. In Japan, off-label CSC treatments are not covered by national health insurance. Photodynamic therapy is globally recognised as the first-line treatment for chronic CSC. Reduced-fluence PDT became the preferred clinical approach for CSC.