Regulatory Logic
NF-kB is used as a representation of inflammatory signaling in the model. The key regulatory logic combines epithelial-mesenchymal antagonism, senescence control, inflammatory signaling, and telomerase-associated immortality. ESE-2 represe…
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NF-kB is used as a representation of inflammatory signaling in the model. The key regulatory logic combines epithelial-mesenchymal antagonism, senescence control, inflammatory signaling, and telomerase-associated immortality. ESE-2 represents epithelial ETS transcription factor activity and represses Snai2. Snai2 represents EMT transcription factor activity that represses epithelial genes and supports mesenchymal identity. p16 and p53 represent senescence-associated tumor suppressive activity, while Rb represses E2F-driven cell-cycle progression.