Rejuvenation

The paper formalizes rejuvenation as a negative expected change in biological age rather than only as a daughter-cell event. A rejuvenation state is defined as a state with negative expected biological-age jump size. State 0 cannot be reju…

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The paper formalizes rejuvenation as a negative expected change in biological age rather than only as a daughter-cell event. A rejuvenation state is defined as a state with negative expected biological-age jump size. State 0 cannot be rejuvenating and state n has zero expected jump size. For n = 100, m = 15, p = 0.5, and alpha = 2, the rejuvenation interval is 19 through 63. In the constant-inflow case, rejuvenation states are either absent or form one interval. Rejuvenation occurs when expected damage removal through division exceeds expected capped damage inflow.